Forging inseparable bonds in childhood that reinforce them throughout their teen years, two girls and three boys go their separate ways as adults and encounter respective tragedies and transformations.

Gabby, Billy, Izzie, Andy, and Sean—each bursting with their own personality, strikingly different looks and talents, in sports, science, and the arts. Each drawn by the magical spark of connection that happens to the young. At the exclusive Atwood School, on a bright September day, starting in kindergarten they become an inseparable group known to outsiders as the Big Five. In this rarefied world, five families grow closer, and five children bloom beside one another, unaware of the storms gathering around them. As they turn from grade-schoolers to teenagers, seemingly perfect lives are buffeted by unraveling families, unfortunate missteps, and losses and victories great and small. And, one by one, they turn back to the Big Five to regain their footing and their steady course. But as they emerge from Atwood and enter the college years, the way forward is neither safe nor clear. As their lives separate and diverge, the challenges and risks become greater, the losses sharper, and the right paths harder to choose, in a journey of friendship, survival, and love.